Sandbox g09
Mycotic aneurysm
- Empiric antimicrobial therapy
- Preferred regimen: Vancomycin 2 g/day IV divided q6-12h targeting trough concentration of 15-20 μg/mL (for critically ill patient, start with a loading dose of 25 mg/kg followed by 15 mg/kg q12h) AND (Ceftriaxone 2 g IV q24h OR Piperacillin-Tazobactam 3.375 g IV q6h OR Ciprofloxacin 400 mg IV q12h)
- Alternative regimen: Consider substituting Daptomycin for Vancomycin. Consider Cefepime, Imipenem-Cilastatin, Meropenem, or Ertapenem for Gram-negative bacteria.
- Note: A 6-week course of antibiotic therapy from the time of surgical procedure is usually required.