Sandbox g16

Dosage adjustment in patients with hepatic disease Return to Top

Dosage adjustment may be required in the presence of hepatic disease for the following medications (consult FDA package insert for details):

Antimicrobial Agent	Category	Recommendation
Abacavir	Antiviral agent	A dose of 200 mg abacavir administered twice daily is recommended for patients with mild liver disease. The safety, efficacy, and pharmacokinetics of abacavir have not been studied in patients with moderate or severe hepatic impairment; therefore, abacavir is contraindicated in these patients.
Atazanavir
Caspofungin
Ceftriaxone
Chloramphenicol
Clindamycin
Darunavir
Delavirdine
Efavirenz
Enfuvirtide
Fosamprenavir
Fusidic acid
Indinavir
Isoniazid
Itraconazole
Lopinavir-Ritonavir
Metronidazole
Nafcillin
Nelfinavir
Nevirapine
Quinupristin-Dalfopristin
Rifabutin
Rifampin
Rimantadine
Ritonavir
Telithromycin
Tigecycline
Tinidazole
Voriconazole