Sandbox sc

Mycobacterium terrae

• Mycobacterium terrae

• 1. In vitro susceptibility

• All six of the isolates from a single center and 90% or more of an additional 22 isolates of M. terrae complex were susceptible to Ciprofloxacin and Sulfonamides. Recently, 11 isolates of M. terrae complex were also shown to be susceptible to Linezolid

• 2. Antimicrobial therapy

• Preferred regimen: Macrolide AND Ethambutol or other agent based on in vitro susceptibility results

Mycobacterium szulgai

• Mycobacterium szulgai

• 1. in vitro susceptibility

• M. szulgai is susceptible in vitro to most antituberculous drugs including Quinolones and newer Macrolides.

• 2. Pulmonary infection

• Preferred regimen: three- or four-drug regimen based on susceptibility that includes 12 months of negative sputum cultures while on therapy

• 3. Extrapulmonary infection

• Preferred regimen: combination anti-tuberculous medications based on in vitro susceptibilities for 4 to 6 months

Mycobacterium smegmatis

• Mycobacterium smegmatis

• 1. Mild disease

• Preferred regimen: Doxycycline PO AND Trimethoprim sulfamethoxazole PO

• 2. Severe disease

• Preferred regimen: Amikacin IV OR Imipenem IV