Bartonellosis medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Treatment of Bartonellosis are specific for each species. Azithromycin, doxycycline and erythromycin are commonly used to treat Bartonellosis.
Medical Therapy
Pharmacotherapy
Treatment of infections caused by Bartonella species.[1][2]
Disease | Adults | Children |
---|---|---|
Cat scratch disease | no recommendation | no recommendation |
Retinitis | Doxycycline + Rifampin | unknown |
Trench fever or chronic bacteremia by B.quintana | Doxycycline + Gentamicin | unknown |
Bacillary angiomatosis | Erythromycin or Doxycycline | Erythromycin |
Peliosis hepatis | Erythromycin or Doxycycline | Erythromycin |
Endocarditis | Doxycycline + Gentamicin + Rifampin or Ceftriaxone + Gentamicin | |
Carrión´s disease (acute phase) | Ciprofloxacin or Chloramphenicol | Chloramphenicol + beta-lactam |
Carrión´s disease (chronic phase: Verruga peruana) | Rifampin or macrolides | Rifampin or macrolides |
Anti microbial regimen
- Bartonella bacilliformis
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- 1. Carrion´s disease or Oroya fever (acute phase of infection) and Verruga peruana or Peruvian wart (chronic phase of infection)
- Preferred regimen:
- Alternative regimen:
- Bartonella henselae
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- Bartonella quintana
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- Bartonellosis[3]
- 1.Cat scratch disease
- 1.1.If extensive adenopathy
- Preferred regimen : Azithromycin 500 mg single dose
- 2.Retinitis
- Preferred regimen : Doxycycline 100 mg bid AND Rifampin 300 mg bid PO for 4-6 weeks.
- 3.Bacillary angiomatosis
- Preferred regimen : Erythromycin 500 mg PO qid OR Doxycycline 100mg PO bid for >3 months.
- 4.Peliosis hepatitis
- Preferred regimen : Erythromycin 500 mg PO qid OR Doxycycline 100 mg PO bid for 4 months.
- 5.Oroya fever
- Preferred regimen : Ciprofloxacin 500 mg PO bid for 10 days.
- 6.Endocarditis
- Preferred regimen : Gentamicin 3 mg/kg/day IV q8h for 14 days AND Ceftriaxone 2 g/day IV for 6 weeks with or without Doxycycline 100 mg PO bid for 6 weeks.
References
- ↑ Rolain JM, Brouqui P, Koehler JE, Maguina C, Dolan MJ, Raoult D (2004). "Recommendations for treatment of human infections caused by Bartonella species". Antimicrob. Agents Chemother. 48 (6): 1921–33. doi:10.1128/AAC.48.6.1921-1933.2004. PMC 415619. PMID 15155180. Unknown parameter
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ignored (help) - ↑ Blanco JR, Raoult D (2005). "[Diseases produced by Bartonella]". Enferm. Infecc. Microbiol. Clin. (in Spanish; Castilian). 23 (5): 313–9, quiz 320. PMID 15899181. Unknown parameter
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ignored (help) - ↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.
[[Category: Infectious Disease Project