Adamantinoma
| Adamantinoma | |
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| Micrograph of an adamantinoma showing the biphasic histomorphology. H&E stain.. | |
| ICD-O: | 9310/0 |
| DiseasesDB | 31676 |
| MeSH | D050398 |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Adamantinoma is a rare bone cancer, making up less than 1% of all bone cancers. It predominantly arises in bone in a subcutaneous location (85% are in the tibia). Most commonly, patients are in their second or third decade, but it can occur over a wide age range.
Historical Perspective
The condition was first described by Fischer in 1913.[1][2]
Pathophysiology
Histologically, islands of epithelial cells are found in a fibrous stroma.
Treatment
Treatment consists of wide resection or amputation. Metastases are rare at presentation but may occur in up to 30% of patients during the disease course. Prognosis is excellent, with overall survival of 85% at 10 years, but is lower when wide surgical margins cannot be obtained.
References
- Campbell's Operative Orthopedics (10th edition ed.). 2003.