Fructose 1,6-bisphosphate

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Fructose 1,6-phosphate is fructose sugar phosphorylated on carbons 1 and 6 (ie. is a fructosephosphate). The β-D-form of this compound is very common in cells. The vast majority of glucose and fructose entering a cell will become converted to fructose 1,6-phosphate at some point.

Fructose 1,6-phosphate in glycolysis

Fructose 1,6-phosphate lies within the glycolysis metabolic pathway and is produced by phosphorylation of fructose 6-phosphate. It is in turn broken down into two compounds; glyceraldehyde 3-phosphate and glycerone phosphate. It is allosteric activator of pyruvate kinase.

The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

Fructose 1,6-phosphate isomerism

Main article: Fructose

Fructose 1,6-phosphate has only one biologically active isomer, the β-D-form. There are many other isomers, analogous to those of fructose.

See also

• Fructose 2,6-bisphosphate