Magnesium sulfate (oral, topical)

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Magnesium sulfate (oral, topical)
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Disclaimer

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Overview

Magnesium sulfate (oral, topical) is a saline laxative that is FDA approved for the treatment of occasional constipation (irregularity). Common adverse reactions include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia..

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • Uses for Oral Laxative
  • for relief of occasional constipation (irregularity)
  • this product generally produces bowel movement in 1/2 to 6 hours
  • For Soaking

Directions

  • do not exceed recommended daily dosage
  • drink a full glass (8 ounces) of liquie with each dose
  • may be taken as a single daily dose or in divided doses
  • dissolve the dose in 8 ounces of water. Lemon juice may be added to improve the taste
  • adults and children 12 years and over - 2 to 6 level teaspoons (10 to 30 grams) daily
  • children 6 to under 12 years - 1 to 2 level teaspoons (5 to 10 grams) daily
  • children under 6 years - consult a doctor
  • Directions for Soaking
  • Directions: Dissolve 2 cupfuls of this product per gallon of water. Apply with bandages or towelling for 30 minutes up to three times a day, or use as a soak or in bath. Use warm water for best results.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium sulfate (oral, topical) in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium sulfate (oral, topical) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Magnesium sulfate (oral, topical) in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium sulfate (oral, topical) in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium sulfate (oral, topical) in pediatric patients.

Contraindications

There is limited information regarding Magnesium sulfate (oral, topical) Contraindications in the drug label.

Warnings

  • Warnings for Soaking
  • CAUTION: If prompt relief is not obtained or there is evidence of infection, discontinue use and consult your physician. Hot or warm soaks should not be used by individuals with diabetes except on the advice of a physician. Keep out of reach of children.
  • Ask a doctor before use if you have
  • kidney disease
  • a magnesium-restricted diet
  • abdominal pain, nausea or vomiting
  • noticed a sudden change in bowel habits that persists over a period of 2 weeks
  • already used a laxative for a period longer than 1 week

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Magnesium sulfate (oral, topical) in the drug label.

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Magnesium sulfate (oral, topical) in the drug label.

Drug Interactions

There is limited information regarding Magnesium sulfate (oral, topical) Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): D

  • If pregnant or breast-feeding, ask a health professional before use.


Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Magnesium sulfate (oral, topical) in women who are pregnant.

Labor and Delivery

  • If pregnant or breast-feeding, ask a health professional before use.

Nursing Mothers

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) with respect to nursing mothers.

Pediatric Use

  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Geriatic Use

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Magnesium sulfate (oral, topical) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Magnesium sulfate (oral, topical) in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Topical

Monitoring

There is limited information regarding Monitoring of Magnesium sulfate (oral, topical) in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Magnesium sulfate (oral, topical) in the drug label.

Overdosage

There is limited information regarding Chronic Overdose of Magnesium sulfate (oral, topical) in the drug label.

Pharmacology

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Template:Chembox header2 | Magnesium sulfate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
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UNII
Properties
MgSO4
Molar mass 120.366 g/mol (anhydrous)
138.38 g/mol (monohydrate)
174.41 g/mol (trihydrate)
210.44 g/mol (pentahydrate)
228.46 g/mol (hexahydrate)
246.47 g/mol (heptahydrate)
Hazards
Related compounds
Template:Chembox header2 | Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Mechanism of Action

There is limited information regarding Magnesium sulfate (oral, topical) Mechanism of Action in the drug label.

Structure

There is limited information regarding Magnesium sulfate (oral, topical) Structure in the drug label.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Magnesium sulfate (oral, topical) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Magnesium sulfate (oral, topical) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Magnesium sulfate (oral, topical) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Magnesium sulfate (oral, topical) in the drug label.

How Supplied

There is limited information regarding Magnesium sulfate (oral, topical) How Supplied in the drug label.

Storage

There is limited information regarding Magnesium sulfate (oral, topical) Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Patient Counseling Information of Magnesium sulfate (oral, topical) in the drug label.

Precautions with Alcohol

  • Alcohol-Magnesium sulfate (oral, topical) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

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Look-Alike Drug Names

There is limited information regarding Magnesium sulfate (oral, topical) Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.



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