Genotoxicity

WikiDoc Resources for Genotoxicity
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Evidence Based Medicine
Cochrane Collaboration on Genotoxicity Bandolier on Genotoxicity TRIP on Genotoxicity
Clinical Trials
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Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Genotoxicity NICE Guidance on Genotoxicity NHS PRODIGY Guidance FDA on Genotoxicity CDC on Genotoxicity
Books
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Commentary
Blogs on Genotoxicity
Definitions
Definitions of Genotoxicity
Patient Resources / Community
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Healthcare Provider Resources
Symptoms of Genotoxicity Causes & Risk Factors for Genotoxicity Diagnostic studies for Genotoxicity Treatment of Genotoxicity
Continuing Medical Education (CME)
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Business
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Experimental / Informatics
List of terms related to Genotoxicity

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Genotoxic substances are a type of carcinogen, specifically those capable of causing genetic mutation and of contributing to the development of tumors. This includes both certain chemical compounds and certain types of radiation.

Typical genotoxins like aromatic amines are believed to cause mutations because they are electrophilic and form strong covalent bonds with DNA, preventing accurate replication.

For more information see Mutagen

References

• http://ehp.niehs.nih.gov/docs/1996/Suppl-6/smith.html Environ Health Perspect 104(Suppl 6):1219-1225 (1996) The Mechanism of Benzene-induced Leukemia: A Hypothesis and Speculations on the Causes of Leukemia]

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