Adrenocortical carcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3]

Overview

Adrenocortical carnioma is classified depending on hormonal production and histological appearance.

Classification

Adrenocortical carcinomas are classified as:

1- Depending on hormones production:

• Functional, produce one or more of the followings hormones:

• Cortisol.
• Aldosterone.
• Testosterone.
• Estrogen.

• Nonfunctional

2- Depending on histology:

• Well differentiated
• Intermediate differentiated
• Poorly differentiated
• Anaplastic

3- Variants include:

• Oncocytic adrenal cortical carcinoma
• Myxoid adrenal cortical carcinoma
• Carcinosarcoma
• Adenosquamous adrenocortical carcinoma
• Clear cell adrenal cortical carcinoma