Diffuse large B cell lymphoma laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Laboratory tests of follicular lymphoma include cytology, genetic testing, histologic confirmation, and immunophenotyping.
Laboratory Tests
Laboratory tests of follicular lymphoma include
- Cytology (for primary CNS lymphoma only)
- Genetic testing
- 8q24/MYC translocations
- Immunoglobulin genes clonally rearranged and hypermutated
- Mutation of BCL6, MYC, PAX5, PIM1, RhoH/TTFn, TP53 genes
- Translocations involving c-MYC, BCL6, and IgH genes
- Histologic confirmation
- ImmunophenotypingBCL-2+, BCL6+/-, CD10+, CD15+, CD20+, CD22+, CD30+, CD79a+, EBNA-2+, Fox-P1+, IRF4/MUM1+, LMP-1+, Surface 4 or cytoplasmic immunoglobulin (Ig) is absent