Cystic nephroma

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST) and renal epithelial stromal tumour (REST),^[1] is a type of rare benign kidney tumour.

Symptoms

Cystic nephromas are often asymptomatic. They are typically discovered on medical imaging incidentally (i.e. an incidentaloma).

Diagnosis

Cystic nephromas are diagnosed by biopsy or excision. It is important to correctly diagnose them as, radiologically, they may mimic the appearance of a renal cell carcinoma that is cystic.^[2]

Pathologic diagnosis

High magnification micrograph of a **cystic nephroma** showing the characteristic simple epithelium with hobnail morphology, and the ovarian-like stroma. H&E stain.

The characteristics of cystic nephromas are:

Cysts lined by a simple epithelium with a hobnail morphology, i.e. the nuclei of the cyst lining epithelium bulges into the lumen of the cysts,
Ovarian-like stroma that has a:
- Spindle cell morphology, and has a
- Basophilic cytoplasm.

Cystic nephromas have an immunostaining pattern like ovarian stroma; they are positive for:

Differential diagnosis

cystic partially differentiated nephroblastoma
cystic standard nephroblastoma (cystic Wilm's tumor)
cystic mesoblastic nephroma
cystic renal cell carcinoma
other renal cysts

Additional images

Micrograph of a cystic nephroma. H&E stain.

Micrograph of a cystic nephroma. H&E stain.

References

↑ Turbiner J, Amin MB, Humphrey PA, et al. (April 2007). "Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term". Am. J. Surg. Pathol. 31 (4): 489–500. doi:10.1097/PAS.0b013e31802bdd56. PMID 17414095.
↑ Small JE et al. Cystic Nephroma. BrighamRAD Teaching Case Database. URL: http://brighamrad.harvard.edu/Cases/bwh/hcache/385/full.html. Accessed: July 25, 2009.

Template:Urologic neoplasia

[pmid17414095-1] Turbiner J, Amin MB, Humphrey PA, et al. (April 2007). "Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term". Am. J. Surg. Pathol. 31 (4): 489–500. doi:10.1097/PAS.0b013e31802bdd56. PMID 17414095.

[2] Small JE et al. Cystic Nephroma. BrighamRAD Teaching Case Database. URL: http://brighamrad.harvard.edu/Cases/bwh/hcache/385/full.html. Accessed: July 25, 2009.

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