Ganglioglioma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Gross Pathology
There is predilection towards the temporal lobes, although gangliglioma may occur in the frontal lobe, parietal lobe, occipital lobe, and regions of the thalamus and third ventricle[1]
Microscopic Pathology
Gangliogliomas are composed of two cell populations:[1]
- Ganglion cells (large mature neuronal elements): ganglio-
- Neoplastic glial elements (primarily astrocytic): -glioma
It is the grade of the glial component that determines biological behaviour. Dedifferentiation into high grade tumours does occasionally occur, and it is usually the glial component (into a glioblastoma multiforme). Only rarely is it the neuronal component (into a neuroblastoma).
Markers
Neuronal origin is demonstrated by positivity to neuronal markers:[1]
- Synaptophysin
- Neuronal specific enolase
- GFAP
References
- ↑ 1.0 1.1 1.2 Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma