21-hydroxylase deficiency natural history, complications and prognosis

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]

Overview

The prognosis of 21-hydroxylase deficient congenital adrenal hyperplasia is usually good, if left untreated, it usually leads to adrenal crisis which is fatal.

Complications

Complication associated with 21-hydroxylase deficient congenital adrenal hyperplasia include:

• Adrenal crisis
• Infertility
• Pre-cautious puberty
• Virilization
• Dehydration

Prognosis

Prognosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency is usually good. But when adrenal crisis happens and is untreated, the patient may die within 1~6 weeks after birth.