Retinoblastoma pathophysiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Retinoblastoma Microchapters |
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Overview
Morphology
Gross appearance Gross and microscopic appearances of retinoblastoma are identical in both hereditary and sporadic types. Macroscopically, viable tumor cells are found near blood vessels, while zones of necrosis are found in relatively avascular areas. Microscopic appearance Microscopically, both undifferentiated and differentiated elements may be present. Undifferentiated elements appear as collections of small, round cells with hyperchromatic nuclei; differentiated elements include Flexner-Wintersteiner rosettes, Homer-Wright rosettes and fluerettes from photoreceptor differentiation.