Hodgkin's lymphoma medical therapy
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Hodgkin's lymphoma Microchapters |
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Hodgkin's lymphoma medical therapy On the Web |
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American Roentgen Ray Society Images of Hodgkin's lymphoma medical therapy |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Patients with early stage disease (IA or IIA) are effectively treated with radiation therapy or chemotherapy. The choice of treatment depends on the age, sex, bulk and the histological subtype of the disease. Patients with later disease (III, IVA, or IVB) are treated with combination chemotherapy alone. Patients of any stage with a large mass in the chest are usually treated with combined chemotherapy and radiation therapy.
Medical Therapy
Chemotherapy
Drug Regimen: ABVDAdriamycin AND Bleomycin AND Vinblastine AND Dacarbazine Drug Regimen: Stanford V Adriamycin AND Bleomycin AND Vinblastine AND Mechlorethamine AND Etoposide AND Prednisone AND RT.
Drug Regimen: BEACOPP Bleomycin AND Etoposide AND Adriamycin AND Cyclophosphamide AND Oncovin AND Procarbazine AND Prednisone
With appropriate treatment, over 93% of Hodgkin's lymphoma cases are curable.
The high cure rates and long survival of many patients with Hodgkin's lymphoma has led to a high concern with late adverse effects of treatment, including cardiovascular disease and second malignancies such as acute leukemias, lymphomas, and solid tumors within the radiation therapy field. Most patients with early stage disease are now treated with abbreviated chemotherapy and involved-field radiation therapy rather than with radiation therapy alone. Clinical research strategies are exploring reduction of the duration of chemotherapy and dose and volume of radiation therapy in an attempt to reduce late morbidity and mortality of treatment while maintaining high cure rates. Hospitals are also treating those who respond quickly to chemo-therapy with no radiation.