Ganglioneuroma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Natural History

  • Ganglioneuromas are rare tumors that most frequently start in the autonomic nerve cells, which may be in any part of the body. The tumor are usually noncancerous (benign).
  • Ganglioneuromas usually occur in people ages 10 to 40. They grow slowly, and may release certain chemicals or hormones.

Complications

Common complications of ganglioneuroma include:

  • If the tumor has been present for a long time and has pressed on the spinal cord or caused other symptoms, surgery to remove the tumor may not necessarily reverse the damage.
  • Compression of the spinal cord may result in loss of movement (paralysis), especially if the cause is not detected promptly.
  • Surgery to remove the tumor may also lead to complications in some cases. However, rare, persistant problems due to compression may occur even after the tumor is removed.

Common complications that can develop as a result of the surgical resection of ganglioneuroma include:[1]

Prognosis

Most ganglioneuromas are noncancerous. The expected outcome is usually good. A ganglioneuroma may, however, become cancerous and spread to other areas, or it may come back after removal.

References

  1. Sánchez-Galán A, Barrena S, Vilanova-Sánchez A, Martín SH, Lopez-Fernandez S, García P; et al. (2014). "Ganglioneuroma: to operate or not to operate". Eur J Pediatr Surg. 24 (1): 25–30. doi:10.1055/s-0033-1358790. PMID 24327216.


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