Ganglioneuroma overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Classification
According to International Neuroblastoma Pathology Classification (INPC), ganglioneuroma may be classified into two subtypes/groups: Ganglioneuroma-maturing and ganglioneuroma-mature.[1]
Pathophysiology
On gross pathology, ganglioneuromas are characterized by solid, white, firm, well-circumscribed, and nodular tumors. On microscopic histopathological analysis, ganglioneuromas are characterized by spindle-shaped cells with cell borders in a fibrillar matrix containing ganglion cells with large round nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. Genes involved in the pathogenesis of ganglioneuroma include MYCN oncogene and chromosome 1p36.
Causes
Differentiating brain tumors from other diseases
Epidemiology and Demographics
Risk factors
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical examination
Laboratory Findings
X Ray
CT
MRI
Ultrasound
Other imaging findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
References
- ↑ Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT; et al. (2009). "Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG". Pediatr Blood Cancer. 53 (4): 563–9. doi:10.1002/pbc.22106. PMC 2730988. PMID 19530234.