Non-Hodgkin lymphoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Classification of Non-Hodgkin lymphoma
| Grade | Description |
|---|---|
| Low-grade or Indolent lymphoma | Indolent lymphomas tend to grow very slowly and there often are few symptoms in the beginning. Because of this, indolent lymphomas tend to widespread by the time they are diagnosed, often involving the bone marrow and spleen.
Indolent lymphomas may need little or no treatment for months or even years. They are often treated only when symptoms appear. Indolent lymphomas can shrink or sometimes seem to disappear with treatment, but they tend to come back. Indolent lymphomas have a fairly good prognosis. People can live many years, although indolent lymphomas are difficult to cure. Some indolent lymphomas can change (transform) into more aggressive lymphomas and so need more aggressive treatment. |
| Common subtype and is composed of numerous classic Reed-Sternberg cells admixed with numerous inflammatory cells including lymphocytes, histiocytes, eosinophils, and plasma cells without sclerosis. This type is most often associated with Epstein–Barr virus (EBV) infection and may be confused with the early, so-called 'cellular' phase of nodular sclerosing classical Hodgkins lymphoma. |
Over the years, doctors have used a variety of terms to classify the many different types of non-Hodgkin's lymphoma . Most often, they are grouped by how the cancer cells look under a microscope and how quickly they are likely to grow and spread. Current lymphoma classification is complex.
MeSH includes four different criteria for classifying NHL. (It is possible to be classified under more than one.)
- High-grade vs. intermediate vs. low-grade: Aggressive lymphomas, also known as intermediate and high-grade lymphomas, tend to grow and spread quickly and cause severe symptoms. Indolent lymphomas, also referred to as low-grade lymphomas, tend to grow quite slowly and cause fewer symptoms. One of the paradoxes of non-Hodgkin's lymphoma is that the indolent lymphomas generally cannot be cured by chemotherapy, while in a significant number of cases aggressive lymphomas can be.
- Diffuse vs. follicular: Follicular lymphoma tends to be indolent, and diffuse lymphoma tends to be aggressive.
- Large cell lymphoma (such as anaplastic large cell lymphoma) vs. Small cell lymphoma vs. Mixed cell lymphoma
Details of the most popular classifications of lymphoma can be found in the lymphoma page.
References
bn:অ-হজকিনের লসিকার্বুদ de:Non-Hodgkin-Lymphom nl:Non-Hodgkin fi:Non-Hodgkinin lymfooma sv: Non-Hodgkins lymfom