Non-Hodgkin lymphoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Non-Hodgkin lymphoma may be classified according to World Health Organization (WHO) into 3 groups: Mature B-cell lymphoma, Mature T-cell and NK-cell lymphoma, and post-transplant lymphoproliferative disorders. Non-Hodgkin lymphoma may be classified into 2 Groups:low-grade or indolent lymphoma and high-grade or aggressive lymphoma.

Classification of Non-Hodgkin lymphoma

A. WHO Classification

• Non-Hodgkin lymphoma may be classified according to World Health Organization (WHO) into 3 groups:

• 1. Mature B-cell lymphoma

• Burkitt lymphoma
• Follicular lymphoma
• Lymphoplasmacytic lymphoma (Waldenström's macroglobulinaemia)
• Lymphomatoid granulomatosis
• Mantle cell lymphoma

• 2. Mature T-cell and NK-cell lymphoma

• Angioimmunoblastic T-cell lymphoma

• 3. Post-transplant lymphoproliferative/lymphoproliferation disorders

B. Classification based on rate of growth

• B. Non-Hodgkin lymphoma may be classified into 2 Groups:

• Low-grade or Indolent lymphoma
• High-grade or Aggressive lymphoma

Non-Hodgkin lymphoma classification

Grade	Description
Low-grade or Indolent lymphoma	Tend to grow very slowly, tend to widespread by the time they are diagnosed, often involving the bone marrow and spleen. Often treated only when symptoms appear. Can shrink or seem to disappear with treatment, but they tend to come back. Can change into more aggressive lymphomas. Have a fairly good prognosis.
High-grade or Aggressive lymphoma	Grow quickly and tend to spread to lymph nodes or other organs throughout the body. Cause symptoms and need treatment right away. Can frequently be successfully treated with intensive chemotherapy treatment.

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