Tumor lysis syndrome natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Tumor lysis syndrome is a life threatening condition that may lead to death if not treated early on. The complications of tumor lysis syndrome are the result of the associated hyperurecemia and electrolytes abnormalities.
Natural History
Tumor lysis syndrome is a life threatening condition that may lead to death if not treated early on.
Complications
- Life-threatening conditions may result in death or permanent disability within 24 hours if left untreated.[1]
- Acute kidney injury
- Arrhythmia
- Seizures
- Tetany
These complications are caused by the break-down products of dying cancer cells and include hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia, and acute renal failure.
References
- ↑ Coiffier B, Altman A, Pui CH, Younes A, Cairo MS (2008). "Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review". J Clin Oncol. 26 (16): 2767–78. doi:10.1200/JCO.2007.15.0177. PMID 18509186.