Non-Hodgkin lymphoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Non-Hodgkin lymphoma may be classified according to updated REAL/WHO classification into 2 groups: B-cell neoplasms and T-cell and putative NK-cell neoplasms. Non-Hodgkin lymphoma may be classified based on rate of growth into 2 Groups:low-grade or indolent lymphoma and high-grade or aggressive lymphoma.
Classification of Non-Hodgkin lymphoma
A. Updated REAL / WHO classification
- Non-Hodgkin lymphoma may be classified according to updated REAL / WHO classification into 2 groups:[1]
- B-cell neoplasms
- T-cell and putative NK-cell neoplasms
| B-cell neoplasms | T-cell and putative NK-cell neoplasms |
|---|---|
| Precursor B-cell neoplasm | Precursor T-cell neoplasm |
| Precursor B-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) | Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) |
| Peripheral B-cell neoplasms | Peripheral T-cell and NK-cell neoplasms |
| B-cell CLL / small lymphocytic lymphoma | T-cell CLL / prolymphocytic leukemia |
| B-cell pro lymphocytic leukemia | T-cell granular lymphocytic leukemia |
| Lymphoplasmacytic lymphoma / immunocytoma | Mycosis fungoides / Sézary syndrome |
| Mantle cell lymphoma | Peripheral T-cell lymphoma, not otherwise characterized |
| Follicular lymphoma | Hepatosplenic gamma / delta T-cell lymphoma |
| Extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type | Subcutaneous panniculitis-like T-cell lymphoma |
| Nodal marginal zone B-cell lymphoma (± mono cytoid B-cells) | Angio immunoblastic T-cell lymphoma |
| Splenic marginal zone lymphoma (± villous lymphocytes) | Extranodal T-/NK-cell lymphoma, nasal type |
| Hairy cell leukemia | Enteropathy-type intestinal T-cell lymphoma |
| Plasmacytoma / plasma cell myeloma | Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+) |
| Diffuse large B-cell lymphoma | Anaplastic large cell lymphoma, primary systemic type |
| Burkitt lymphoma | Anaplastic large cell lymphoma, primary cutaneous type |
| Aggressive NK-cell leukemia |
B. Classification based on rate of growth
- Non-Hodgkin lymphoma may be classified based on rate of growth into 2 Groups:[2]
- Low-grade or Indolent lymphoma
- High-grade or Aggressive lymphoma
| Grade | Description |
|---|---|
| Low-grade or Indolent lymphoma |
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| High-grade or Aggressive lymphoma |
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References
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
- ↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".