Hodgkin's lymphoma classification

Hodgkin's lymphoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Hodgkin's lymphoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
Staging
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray Findings
CT
MRI
Ultrasound
Biopsy
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Hodgkin's lymphoma classification On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Hodgkin's lymphoma classification All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Hodgkin's lymphoma classification
CDC on Hodgkin's lymphoma classification
Hodgkin's lymphoma classification in the news
Blogs on Hodgkin's lymphoma classification
Directions to Hospitals Treating Hodgkin's lymphoma
Risk calculators and risk factors for Hodgkin's lymphoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Hodgkin's lymphoma may be classified according to World Health Organization (WHO) into 2 subtypes: nodular lymphocyte predominant and classical Hodgkin's lymphoma.

Classification

Hodgkin's lymphoma may be classified according to World Health Organization (WHO) into 2 subtypes:

• Nodular lymphocyte predominant

• Classical Hodgkin's lymphoma

• Nodular sclerosing
• Mixed cellularity
• Lymphocyte rich
• Lymphocyte depleted

Classical Hodgkin's lymphoma classification

Name	Description
Nodular sclerosing	Most common subtype and is composed of large tumor nodules showing scattered lacunar classical Reed–Sternberg cells set in a background of reactive lymphocytes, eosinophils, and plasma cells with varying degrees of collagen fibrosis/sclerosis.
Mixed-cellularity	Common subtype and is composed of numerous classic Reed-Sternberg cells admixed with numerous inflammatory cells including lymphocytes, histiocytes, eosinophils, and plasma cells without sclerosis. This type is most often associated with Epstein–Barr virus (EBV) infection and may be confused with the early, so-called 'cellular' phase of nodular sclerosing classical Hodgkins lymphoma.
Lymphocyte rich	Rare subtype, show many features which may cause diagnostic confusion with nodular lymphocyte predominant B-cell Non-Hodgkin's Lymphoma (B-NHL). This form also has the most favorable prognosis.
Lymphocyte depleted	Rare subtype, composed of large numbers of often pleomorphic Reed-Sternberg cells with only few reactive lymphocytes which may easily be confused with diffuse large cell lymphoma. Many cases previously classified within this category would now be reclassified under anaplastic large cell lymphoma.

References

Template:WikiDoc Sources