Multiple myeloma future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Vidit Bhargava, M.B.B.S [2]
- Lymphoma-like polychemotherapy regimen "Dexa-BEAM" (including dexamethasone, carmustine, cytarabine, etoposide and melphalan) in treating advanced and extramedullary multiple myeloma has been studied by Rasche L etal. It showed improved survival, when used as a bridge to stem cell transplantation.[1]
- Carfilzomib is a new proteasome inhibitor that selectively and irreversibly binds to its target, resulting in sustained inhibition. It thus has a better response as compared to bortezomib along with a favorable safety profile. Clinical trials have been approved and under process to study the effects of the drug. The prospect of its combination with several other agents such as immunomodulators, alkylating agents, glucocorticoids, histone deacetylase inhibitors and kinesin spindle protein inhibitors also holds promise.[2]
- Eda etal is studying a novel Bruton's tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib and its rols as anti-multiple myeloma combiantion therpay.[3]
- Ibrutinib (Imbruvica™) is a small molecule, first-in-class, once-daily, orally available, Bruton's tyrosine kinase inhibitor that is under development for the treatment of B cell malignancies, including chronic lymphocytic leukaemia (CLL), mantle cell lymphoma (MCL) and diffuse large B cell lymphoma (DLBCL), as well as multiple myeloma (MM), follicular lymphoma (FL) and Waldenstrom's macroglobulinemia (WM).[4]
- A series of degrasyn like compounds (T5165804 and CP2005) are being studied and have showed higher efficacy against tumor cells and can be used as potential carcinoma therapy in the future.[5]
References
- ↑ Rasche, L.; Strifler, S.; Duell, J.; Rosenwald, A.; Buck, A.; Maeder, U.; Einsele, H.; Knop, S. (2014). "The lymphoma-like polychemotherapy regimen Dexa-BEAM in advanced and extramedullary multiple myeloma". Ann Hematol. doi:10.1007/s00277-014-2023-2. PMID 24526137. Unknown parameter
|month=ignored (help) - ↑ Moreau, P. (2014). "The emerging role of carfilzomib combination therapy in the management of multiple myeloma". Expert Rev Hematol. doi:10.1586/17474086.2014.873699. PMID 24521249. Unknown parameter
|month=ignored (help) - ↑ Eda, H.; Santo, L.; Cirstea, DD.; Yee, A.; Scullen, TA.; Nemani, N.; Mishima, Y.; Waterman, PR.; Arastu-Kapur, S. (2014). "A novel Bruton's tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant anti-myeloma activity". Leukemia. doi:10.1038/leu.2014.69. PMID 24518207. Unknown parameter
|month=ignored (help) - ↑ Cameron, F.; Sanford, M. (2014). "Ibrutinib: first global approval". Drugs. 74 (2): 263–71. doi:10.1007/s40265-014-0178-8. PMID 24464309. Unknown parameter
|month=ignored (help) - ↑ Peng, Z.; Maxwell, DS.; Sun, D.; Bhanu Prasad, BA.; Schuber, PT.; Pal, A.; Ying, Y.; Han, D.; Gao, L. (2014). "Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)". Bioorg Med Chem. 22 (4): 1450–8. doi:10.1016/j.bmc.2013.12.048. PMID 24457091. Unknown parameter
|month=ignored (help)