Osteosarcoma surgery

Osteosarcoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Surgery

• Cure, if achievable requires aggressive surgical resection often with amputation followed by chemotherapy.
• If a limb-salvage procedure is feasible, a course of multi-drug chemotherapy precedes surgery to downstage the tumor, followed by wide resection of the bone and insertion of an endoprosthesis.
• The outcome depend on different factors such as age, sex, site, size, and type but the most important predictor is the histologic degree of necrosis post induction chemotherapy; 90% histologic necrosis is associated with much better prognosis.