Meningioma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Common risk factors in the development of meningioma are history of radiation treatment, inherited nervous system disorder, and female gender.[1][2][3]

Risk Factors

The table below lists the risk factors for multiple myeloma:

Risk Factor Description
Age The chance to develop multiple myeloma increases as patients get older, where only 1% of multiple myeloma cases are diagnosed in patients younger than 35 years.[4][5][6]
Race African American and Native Pacific Islanders descents are at increased risk of developing multiple myeloma.[1][6][7]
Gender Males are more commonly affected with multiple myeloma than females. The male to female ratio is approximately 2 to 1.[5][6]
Having other plasma cell diseases Patients with other plasma cell diseases such as monoclonal gammopathy of undetermined significance develop multiple myeloma later in their lives.[8][6]
Family history A familial predisposition to myeloma exists due to hyperphosphorylation of specific proteins that may contribute to a higher rates of multiple myeloma in certain groups.[9][1][10][6]
Obesity Being overweight increases a person's risk of developing multiple myeloma.[8][6]
Workplace exposures Petroleum workers and farmers tend to have higher incidence of multiple myeloma relative to other occupations.[11][8][6]
Radiation Areas with previous history of atoms bombs or nuclear accidents had higher risk of multiple myeloma due to increased rate of radiation exposure.[8][6]


  • Radiation treatment: Clinical data suggests that head radiation therapy increase the risk of developing meningioma.
  • An inherited nervous system disorder: Studies show the rare disorder neurofibromatosis type 2 increases the risk of meningioma and other brain tumors.
  • Female hormones: As a tumor common in women than men, doctors believe that female hormones may play an important role in developing meningioma.

References

  1. ↑ 1.0 1.1 1.2 Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#Signs_and_symptoms Accessed on September, 25th 2015
  2. ↑ Risk factors for brain and spinal cord cancer. Canadian Cancer Society(2015) http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/risks/?region=mb Accessed on September, 25th 2015
  3. ↑ Wiemels J, Wrensch M, Claus EB (2010). "Epidemiology and etiology of meningioma". J Neurooncol. 99 (3): 307–14. doi:10.1007/s11060-010-0386-3. PMC 2945461. PMID 20821343.
  4. ↑ Press Releases. Compugen (2015)http://www.cgen.com/media-center/press-releases/-314 Accessed on September, 20th 2015
  5. ↑ 5.0 5.1 Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Multiple myeloma. The American Cancer Society (2015) http://www.cancer.org/cancer/multiplemyeloma/detailedguide/multiple-myeloma-risk-factors Accessed on September, 20 2015
  7. ↑ Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015
  8. ↑ 8.0 8.1 8.2 8.3 Multiple myeloma. MedlinePlus (2015)http://www.wikidoc.org/index.php?title=Multiple_myeloma_risk_factors&action=edit&section=2 Accessed on Septmeber, 20th 2015
  9. ↑ Bourguet, CC.; Grufferman, S.; Delzell, E.; DeLong, ER.; Cohen, HJ. (1985). "Multiple myeloma and family history of cancer. A case-control study". Cancer. 56 (8): 2133–9. PMID 4027940. Unknown parameter |month= ignored (help)
  10. ↑ Koura DT, Langston AA (2013). "Inherited predisposition to multiple myeloma". Ther Adv Hematol. 4 (4): 291–7. doi:10.1177/2040620713485375. PMC 3734900. PMID 23926460.
  11. ↑ Gallagher, RP.; Spinelli, JJ.; Elwood, JM.; Skippen, DH. (1983). "Allergies and agricultural exposure as risk factors for multiple myeloma". Br J Cancer. 48 (6): 853–7. PMID 6652026. Unknown parameter |month= ignored (help)


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