Mediastinitis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

If left untreated, fibrosing mediastinitis may progress into sepsis and subsequently, death.^[1] Mortality rates related to mediastinitis vary, though some estimates predict rates greater than 60%.^[2] The most severe complication is sepsis, which could result in death.

Natural History

If left untreated, fibrosing mediastinitis may progress into sepsis and subsequently, death.^[1] Mortality rates related to mediastinitis vary, though some estimates predict rates greater than 60%.^[2]

Complications

Common complications include the following:^[1]^[3]

Development of sepsis
Spread of the infection to the:
- Bloodstream
- Blood vessels
- Bones
- Heart
- Lungs
Scarring
Pneumonia

Prognosis

Mediastinitis may be treated with antibiotics, depending on the severity of the infection. The presence of mediastinitis among patients following chest surgery is observed to have a particularly poor prognosis; there is a serious risk of death.

References

↑ ^1.0 ^1.1 ^1.2 Mediastinitis: a potentially lethal infection. Thoracics (2012). http://thoracics.org/2012/03/03/mediastinitis-noncardiac-surgery/ Accessed on September 25, 2015.
↑ ^2.0 ^2.1 Martínez Vallina P, Espinosa Jiménez D, Hernández Pérez L, Triviño Ramírez A (2011). "[Mediastinitis]". Arch Bronconeumol. 47 Suppl 8: 32–6. doi:10.1016/S0300-2896(11)70065-5. PMID 23351519.
↑ Fibrosing Mediastinitis. National Organization for Rare Disorders (2015). https://rarediseases.org/rare-diseases/fibrosing-mediastinitis/ Accessed on September 25, 2015

Template:WikiDoc Sources

[AAA-1] 1.0 ^1.1 ^1.2 Mediastinitis: a potentially lethal infection. Thoracics (2012). http://thoracics.org/2012/03/03/mediastinitis-noncardiac-surgery/ Accessed on September 25, 2015.

[pmid23351519-2] 2.0 ^2.1 Martínez Vallina P, Espinosa Jiménez D, Hernández Pérez L, Triviño Ramírez A (2011). "[Mediastinitis]". Arch Bronconeumol. 47 Suppl 8: 32–6. doi:10.1016/S0300-2896(11)70065-5. PMID 23351519.

[3] Fibrosing Mediastinitis. National Organization for Rare Disorders (2015). https://rarediseases.org/rare-diseases/fibrosing-mediastinitis/ Accessed on September 25, 2015

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