Mediastinitis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Mediastinitis is the inflammation or infection of the mediastinitum.[1] Although the pathogenesis of the infection remains unknown, radiographic, serologic, or histopathologic evidence of prior Histoplasma capsulatum infection, histoplasmosis, or chronic granulomatous disease is always observed. [2]
Pathophysiology
Gross Pathology
On gross pathology, characteristic findings of mediastinitis include:
- White, fibrotic mass
- Distinct gap with adipose fat
Microscopic Pathology
On microscopic histopathological analysis, characteristic findings of mediastinitis include:
References
- ↑ Koksal D, Bayiz H, Mutluay N, Koyuncu A, Demirag F, Dagli G; et al. (2013). "Fibrosing mediastinitis mimicking bronchogenic carcinoma". J Thorac Dis. 5 (1): E5–7. doi:10.3978/j.issn.2072-1439.2012.07.03. PMC 3548007. PMID 23372962.
- ↑ Histopathologic Overlap between Fibrosing Mediastinitis and IgG4-Related Disease. International Journal of Rheumatology (2012). http://www.hindawi.com/journals/ijr/2012/207056/ Accessed on September 25, 2015