Carcinoid syndrome causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Common causes of carcinoid syndrome include genetic disorders ([multiple endocrine neoplasia type 1]] and neurofibromatosis type 1) and genetic mutations (gains involving chromosomes 5, 14, 17, and 19 and losses involving chromosomes 11 and 18.[1]
Causes
Common causes of carcinoid syndrome include:[2]
- Genetic disorders
- Multiple endocrine neoplasia type 1
- Carcinoids associated with multiple endocrine neoplasia type 1 appear to be of foregut origin.
- Neurofibromatosis type 1
- Carcinoids in patients with neurofibromatosis type 1 appear to arise primarily in the periampullary region.
- Multiple endocrine neoplasia type 1
- Genetic mutations
- Gains involving chromosomes 5, 14, 17, and 19
- Losses involving chromosomes 11 and 18
References
- ↑ Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq
- ↑ Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq