Carcinoid syndrome history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Symptoms of carcinoid tumor include flushing, diarrhea, wheezing, abdominal cramps, wheezing, and cough.
History
When evaluating a patient for carcinoid syndrome, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough past medical history review. Other specific areas of focus when obtaining the history are:
- Review of any family history of predisposing genetic disorders such as multiple endocrine neoplasia type 1 or neurofibromatosis type 1
Symptoms
Carcinoid Syndrome
Common symptoms of carcinoid syndrome include:
- Flushing
- Diarrhea
- Wheezing
- Abdominal cramping
- Swelling of leg
This constellation of symptoms is called carcinoid syndrome or (if acute) carcinoid crisis. Occasionally, hemorrhage or pressure effects of the tumor are the presenting symptoms.
Lung Carcinoid Tumor
Thymic Carcinoids
Approximately 40% of patients with thymic carcinoid have Cushing syndrome as a result of adrenocorticotropic hormone secretion by the tumor.
Carcinoid Heart Disease
Carcinoid heart disease develops in more than one-third of patients with carcinoid syndrome. Symptoms include:[1]
- Tricuspid and pulmonic regurgitation
- Pulmonary stenosis
- Mitral and aortic insufficiency
- Cardiac dysrhythmias
References
- ↑ General Information About Gastrointestinal (GI) Carcinoid Tumors . National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq#link/_49_toc Accessed on September 24, 2015