Osteosarcoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Osteosarcomas may be classified into several subtypes based on differentiation, location within the bone, and histological variants.

Classification

The World Health Organization’s histologic classification of bone tumors separates the osteosarcomas into central (medullary) and surface (peripheral) tumors and recognizes a number of subtypes within each group.

Central (medullary) tumors:

• Conventional central osteosarcomas.
• Telangiectatic osteosarcomas.
• Intraosseous well-differentiated (low-grade) osteosarcomas.
• Small-cell osteosarcomas.

Surface (peripheral) tumors:

• Parosteal (juxtacortical) well-differentiated (low-grade) osteosarcomas.
• Periosteal osteosarcoma: Low-grade to intermediate-grade osteosarcomas.
• High-grade surface osteosarcomas.

Extraskeletal:

• Extraskeletal osteosarcomas.