Medulloblastoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Medulloblastoma may be classified into several subtypes based on WHO histological classification criteria (classic vs variant medulloblastoma) and the molecular subtypes classification criteria (WNT subgroup vs SHH subgroup vs Group 3 medulloblastoma vs Group 4 medulloblastoma).[1][2][3][4][5]
Classification
WHO histological classification criteria
- Medulloblastoma may be classified into two subtypes based on WHO histological classification criteria which include classic medulloblastoma and variant medulloblastoma.
- Other variants of medulloblastoma include desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic medulloblastoma and medulloblastoma with extensive nodularity.[4][5][2]
WHO histological classification criteria | |||||||||||||||||||||||||||||||||||||||
Classic medulloblastoma | Variant medulloblastoma | ||||||||||||||||||||||||||||||||||||||
Desmoplastic medulloblastoma | Large cell medulloblastoma | Anaplastic medulloblastoma | Medulloblastoma with extensive nodularity | ||||||||||||||||||||||||||||||||||||
Molecular classification criteria
- Medulloblastoma may be classified into at least four major subtypes based on molecular classification criteria which include WNT subgroup, SHH subgroup, Group C and Group D medulloblastoma.[1][3]
Genomic classification criteria | |||||||||||||||||||||||||||||||||||||||
WNT subgroup | Sonic hedgehog (SHH) subgroup | Group 3 medulloblastoma | Group 4 medulloblastoma | ||||||||||||||||||||||||||||||||||||
Risk stratification criteria
- Medulloblastoma may be stratified based on the patient age, tumor stage, and the extent of any previous surgical excision into either a standard (average) risk group or a high risk group.
- The risk stratification criteria may help predict the treatment protocol that should be used for medulloblastoma patients.
References
- ↑ 1.0 1.1 Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T; et al. (2012). "Subgroup-specific structural variation across 1,000 medulloblastoma genomes". Nature. 488 (7409): 49–56. doi:10.1038/nature11327. PMC 3683624. PMID 22832581.
- ↑ 2.0 2.1 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A; et al. (2007). "The 2007 WHO classification of tumours of the central nervous system". Acta Neuropathol. 114 (2): 97–109. doi:10.1007/s00401-007-0243-4. PMC 1929165. PMID 17618441.
- ↑ 3.0 3.1 Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
- ↑ 4.0 4.1 Medulloblastoma. Librepathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28th 2015
- ↑ 5.0 5.1 Medulloblastoma. radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28th 2015