Meningioma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Meningioma may be classified according to the histological criteria of the WHO into 3 groups: benign classic meningioma (WHO grade 1), atypical meningioma (WHO grade 2), and anaplastic malignant meningioma (WHO grade 3). Meningioma may also be classified according to the tumor location into 2 main subtypes: intradural and extradural meningioma.

Classification

• Meningioma may be classified according to the histological criteria of the WHO into 3 groups: benign classic meningioma (WHO grade 1), atypical meningioma (WHO grade 2), and anaplastic malignant meningioma (WHO grade 3).

• Benign classic meningiomas are low-grade (WHO grade I) tumors that grow very slowly and rarely invade the surrounding tissues.
• Atypical meningioma (WHO grade 2) are not clearly malignant, but grow faster than benign meningiomas.
• Anaplastic malignant meningioma (WHO grade 3) tend to grow rapidly and invade the surrounding tissue.

• The table below lists the subtypes of meningioma according to the WHO grades:

WHO grade	Subtypes
Benign classic meningioma (WHO grade 1)	Meningothelial meningioma, fibroblastic meningioma, transitional meningioma, psammomatous, angiomatous meningioma, microcystic meningioma, secretory meningioma, lymphoplasmacyte-rich meningioma, metaplastic meningioma
Atypical meningioma (WHO grade 2)	Choroid meningioma, clear cell meningioma
Anaplastic malignant meningioma (WHO grade 3)	Rhabdoid meningioma, papillary meningioma

• Meningioma may also be classified according to the tumor location into 2 main subtypes: intradural and extradural meningioma.