Anaplastic large cell lymphoma medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive radiotherapy, stem cell transplantation and surgery may be required.

Medical Therapy

• The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive radiotherapy, stem cell transplantation and surgery may be required.

Treatment for anaplastic large cell lymphoma

Type	Chemotherapy	Radiotherapy	Stem cell transplant	Surgery
Primary cutaneous anaplastic large cell lymphoma	Only used for people with extensive disease, where many areas of the skin are affected Used for people cannot be treated with localized treatment	External beam radiation therapy to the area (for localized disease)	--------	Surgery to remove the affected skin
Primary systemic anaplastic large cell lymphoma	Drug Regimen: (CHOP) Cyclophosphamide AND Doxorubicin AND Vincristine AND Prednisone	May be offered	May be offered	--------

Chemotherapy

• Anaplastic large cell lymphoma usually responds well to chemotherapy, so it often has a good prognosis
• It is treated with the same combinations of chemotherapy drugs used to treat other aggressive lymphomas
• Drug Regimen: (CHOP) Cyclophosphamide AND Doxorubicin AND Vincristine AND Prednisone

Radiation therapy

• Radiation therapy is most often given after chemotherapy
• External beam radiation therapy may be used

• When the lymphoma cells are only in one area of the lymph nodes (stage I primary systemic anaplastic large cell lymphoma)
• For localized skin lesions in primary cutaneous anaplastic large cell lymphoma

Stem cell transplant

• A stem cell transplant may be offered to some people with anaplastic large cell lymphoma who relapse after initial treatment

• Overall better prognosis than other "Aggressive Lymphomas"
  • ALK+ 5-year survival 70-80%
  • ALK- 5-year survival 30-40%