Ependymoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Risk Factors
- Children with certain hereditary diseases, such as neurofibromatosis type II (NF2), have been found to be more frequently afflicted with ependymal tumors
- increased occurrence of chromosome 1q and proteins such as tenascin C and epidermal growth factor is associated with increased risk for developing ependymal tumors.
- ERBB2, ERBB4, and human telomerase reverse transcriptase TERT gene expression promote tumor cell proliferation, contributing to aggressive tumor behavior.<ref name=Wikipedia> Ependymoma
- High expression of epidermal growth factor receptor EGFR correlates with unfavorable outcome.[9]
- Over-expression of kinetochore proteins and down-regulation of metallothioneins are associated with recurrence in ependymomas.[11]
[12]
- KIT receptor tyrosine kinase and phospho-KIT were found to be present in pediatric ependymomas and may be involved in angiogenesis associated with those tumors.