Retinoblastoma pathophysiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name]. On microscopic histopathological analysis, [feature1], [feature2], and feature3] are characteristic findings of [disease name].
Gross Pathology
Macroscopically, viable tumor cells are found near blood vessels, while zones of necrosis are found in relatively avascular areas. Macroscopic examination reveals a white elevated mass with fine surface vessels. Early retinoblastoma presents as a solitary or multifocal, well-circumscribed translucent mass. The tumor becomes more pink in color, with dilated feeding blood vessels, as the disease advances. The tumor may exhibit three patterns of growth: