Zollinger-Ellison syndrome natural history, complications and prognosis
|
Zollinger-Ellison syndrome Microchapters |
|
Differentiating Zollinger-Ellison syndrome from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Zollinger-Ellison syndrome natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Zollinger-Ellison syndrome natural history, complications and prognosis |
|
FDA on Zollinger-Ellison syndrome natural history, complications and prognosis |
|
CDC on Zollinger-Ellison syndrome natural history, complications and prognosis |
|
Zollinger-Ellison syndrome natural history, complications and prognosis in the news |
|
Blogs on Zollinger-Ellison syndrome natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
If left untreated, patients with Zollinger-Ellison syndrome may progress to develop abdominal pain, diarrhea, and heartburn.[1] Common complications of Zollinger-Ellison syndrome include upper gastrointestinal bleeding, anemia, and duodenal ulcer perforation. Prognosis is generally good, and the 5 and 10-year survival rate of patients with Zollinger-Ellison syndrome is approximately 94% and 75%, respectively.[2]
Natural History
- If left untreated, patients with Zollinger-Ellison syndrome may progress to develop abdominal pain, diarrhea, and heartburn.[1]
- The symptoms of Zollinger-Ellison syndrome usually develop in the third decade of life. Without treatment, the patient will develop symptoms of gastrinoma, which may eventually lead to anemia and death.[3]
Complications
Common complications associated with Zollinger-Ellison syndrome include:
Prognosis
The prognosis of Zollinger-Ellison syndrome is good with treatment and the 5 and 10-year survival rate of patients with Zollinger-Ellison syndrome is approximately 94% and 75%, respectively. Without treatment, Zollinger-Ellison syndrome may result in weight loss, anemia, and death.[2]
References
- ↑ 1.0 1.1 Roy PK, Venzon DJ, Shojamanesh H, Abou-Saif A, Peghini P, Doppman JL; et al. (2000). "Zollinger-Ellison syndrome. Clinical presentation in 261 patients". Medicine (Baltimore). 79 (6): 379–411. PMID 11144036.
- ↑ 2.0 2.1 Melvin WS, Johnson JA, Sparks J, Innes JT, Ellison EC (1993). "Long-term prognosis of Zollinger-Ellison syndrome in multiple endocrine neoplasia". Surgery. 114 (6): 1183–8. PMID 7903006.
- ↑ Riegert-Johnson D, Gleeson FC, Westra W, et al. Peutz-Jeghers Syndrome. 2008 Jul 18 [Updated 2008 Aug 9]. In: Riegert-Johnson DL, Boardman LA, Hefferon T, et al., editors. Cancer Syndromes [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009-. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1826/