Gestational trophoblastic neoplasia history and symptoms

Template:Choriocarcinoma Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]{{AE}Monalisa Dmello, M.B,B.S., M.D. [2]

Overview

Symptoms of choriocarcinoma include vaginal bleeding, passing of tissue resembling a “bunch of grapes” from the vagina, and the abdomen may grow at a much faster rate than with a normal pregnancy.

History

The medical history is a record of present symptoms, risk factors and all the medical events and problems a person has had in the past. The medical history of a person’s family may also help the doctor to diagnose GTD. In taking a medical history, the doctor will ask questions about:

• A personal history of
• Previous pregnancies, including hydatidiform mole (molar pregnancy) and miscarriage
• Previous GTD
• Reproductive factors that may increase the risk of GTD
• A family history of GTD
• Signs and symptoms that may suggest GTD

Symptoms

Early symptoms of gestational trophoblastic disease

• Vaginal bleeding
• The abdomen may grow at a much faster rate than with a normal pregnancy
• Nausea and vomiting
• Passing of tissue resembling a “bunch of grapes” from the vagina
• Absent fetal movement during pregnancy

Rare symptoms of gestational trophoblastic disease

• Headache
• Edema of the hands and feet
• Abdominal or pelvic pain
• Vaginal discharge
• Overactive thyroid gland (hyperthyroidism) that causes:

• Tachycardia
• Sweating
• Shaking
• Heat intolerance
• Fever

Late symptoms gestational trophoblastic disease

• Hemoptysis
• Dry cough
• Chest pain
• Trouble breathing
• Headache
• Dizziness
• Jaundice
• Paralysis
• Seizure
• Dysarthria and dysphasia
• Vision problems
• Lump in the vagina