Gestational trophoblastic neoplasia staging
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Overview
According to the FIGO cancer staging system, there are 4 stages of choriocarcinoma.
Staging
| Stage | FIGO Anatomical Staging |
|---|---|
|
I |
Disease confined to the uterus |
|
II |
GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament) |
|
III |
GTN extends to the lungs, with or without known genital tract involvement |
|
IV |
All other metastatic sites |
| Modified WHO Prognostic Scoring System as Adapted by FIGO | ||||
| Scores | 0 | 1 | 2 | 4 |
| Age | <40 | ≥40 | – | – |
| Antecedent pregnancy | mole | abortion | term | – |
| Interval months from index pregnancy | <4 | 4–6 | 7–12 | >12 |
| Pretreatment serum hCG (iu/1) | <103 | 103–104 | 104–105 | >105 |
| Largest tumor size (including uterus) | <3 | 3–4 cm | ≥5 cm | – |
| Site of metastases | lung | spleen, kidney | gastrointestinal | liver, brain |
| Number of metastases | – | 1–4 | 5–8 | >8 |
| Previous failed chemotherapy | – | – | single drug | ≥2 drugs" |