Oligoastrocytoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Pathogenesis
- Oligoastrocytomas are mixed tumors that arises from the proliferation of both oligodendrocytes and astrocytes.[1]
- Oligoastrocytomas are low-grade (grade II) tumors. Anaplastic oligoastrocytomas are high-grade (grade III) tumors that occur in the brain.[2]
Genetics
- Development of oligoastrocytoma is the result of multiple genetic mutations.
- Oligoastrocytomas are mixed tumors that have overlapping molecular genetics with both oligodendrogliomas and astrocytomas.[3]
- Genes associated with the pathogenesis of oligoastrocytoma include:[3][4]
Gross Pathology
- On gross pathology, oligoastrocytoma is characterized by
Gallery
Microscopic Pathology
On microscopic histopathological analysis, oligoastrocytoma is characterized by:
On microscopic histopathological analysis, anaplastic oligoastrocytoma is characterized by:
Gallery
Immunohistochemistry
Oligoastrocytoma is demonstrated by positivity to tumor markers such as:[5]
References
- ↑ Introduction of oligodendroglioma and oligoastrocytoma. American Brain Tumor Association. http://www.abta.org/secure/oligodendrioma-oligo.pdf. Accessed on October 16, 2015
- ↑ Mixed Gliomas. Canadian ?Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on#ixzz3okGrTzyi. Accessed on October 16, 2015
- ↑ 3.0 3.1 Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). "Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets". Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.
- ↑ Sahm F, Reuss D, Koelsche C, Capper D, Schittenhelm J, Heim S; et al. (2014). "Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma". Acta Neuropathol. 128 (4): 551–9. doi:10.1007/s00401-014-1326-7. PMID 25143301.
- ↑ IHC of oligoastrocytoma. Librepathology 2015. http://librepathology.org/wiki/index.php/Oligoastrocytoma. Accessed on October 16, 2015