Blue sclera
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Differential Diagnosis
In alphabetical order. [1] [2]
- Alkaptonuria
- Crouzon Syndrome
- Ehlers-Danlos Syndrome
- Enlarged globe
- Infantile glaucoma
- Iron deficiency anemia
- Keratoconus
- Marfan's Syndrome
- Osteogenesis imperfecta
- Paget's Disease
- Scleral ectasia
- Scleral staphyloma
Overview
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
Causes by Organ System
Cardiovascular | Loeys-dietz syndrome, |
Chemical / poisoning | No underlying causes |
Dermatologic | No underlying causes |
Drug Side Effect | Retigabine |
Ear Nose Throat | Van der hoeve's syndrome |
Endocrine | Laron dwarfism |
Environmental | No underlying causes |
Gastroenterologic | No underlying causes |
Genetic | Alkaptonuria , developmental delay hypotonia extremities hypertrophy, ehlers-danlos syndrome, incontinentia pigmenti, juvenile paget disease, laron dwarfism, lobstein disease , loeys-dietz syndrome, marfan's syndrome , marshall-smith-weaver syndrome, metaphyseal chondrodysplasia, recessive type, osteogenesis imperfecta, paget disease juvenile type, recurrent hereditary polyserositis, willems de vries syndrome. |
Hematologic | Diamond-blackfan anemia, hypophosphatasia. |
Iatrogenic | No underlying causes |
Infectious Disease | No underlying causes |
Musculoskeletal / Ortho | Ehlers-danlos syndrome , juvenile paget disease, lobstein disease , loeys-dietz syndrome, marfan's syndrome , marshall-smith-weaver syndrom metaphyseal chondrodysplasia, recessive type, osteogenesis imperfecta, osteoporosis-pseudoglioma syndrome, paget disease juvenile type, pelvic dysplasia arthrogryposis of lower limbs, pilo dento ungular dysplasia microcephaly, pseudoxanthoma elasticum, ray-peterson-scott syndrome, spondyloepimetaphyseal dysplasia joint laxity, van der hoeve's syndrome. |
Neurologic | Bd syndrome, chitayat-moore-del bigio syndrome, daentl-townsend-siegel syndrome, developmental delay hypotonia extremities hypertrophy, Osteoporosis-pseudoglioma syndrome, ray-peterson-scott syndrome. |
Nutritional / Metabolic | Alkaptonuria , hypophosphatasia. |
Obstetric/Gynecologic | No underlying causes |
Oncologic | No underlying causes |
Ophthalmologic | Alkaptonuria , Bd syndrome , Diamond-blackfan anemia, Ehlers-danlos syndrome, Grant syndrome, hypophosphatasia, incontinentia pigmenti , Marfan's syndrome , metaphyseal chondrodysplasia, recessive type, osteogenesis imperfecta, recurrent hereditary polyserositis, Van der hoeve's syndrome, Vater-like syndrome, with pulmonary hypertension, abnormal ears and growth deficiency . |
Overdose / Toxicity | No underlying causes |
Psychiatric | Chitayat-moore-del bigio syndrome |
Pulmonary | No underlying causes |
Renal / Electrolyte | Daentl-townsend-siegel syndrome |
Rheum / Immune / Allergy | No underlying causes |
Sexual | No underlying causes |
Trauma | No underlying causes |
Urologic | No underlying causes |
Miscellaneous | No underlying causes |
Causes in Alphabetical Order
- Alkaptonuria
- Bd syndrome
- Chitayat-moore-del bigio syndrome
- Daentl-townsend-siegel syndrome
- Developmental delay -- hypotonia extremities hypertrophy
- Diamond-blackfan anemia
- Ehlers-danlos syndrome
- Grant syndrome
- Hypophosphatasia Fried Spine Disorder, FSD-1
- Marshall-smith-weaver syndrome Fried Spine Disorder, FSD-1
- Normal in newborns IPFS-1
- Ray-peterson-scott syndrome Animalitic Virus
- Spondyloepimetaphyseal dysplasia joint laxity Animalitic Virus