Renal oncocytoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
On gross pathology, tan or mahogany brown, well circumscribed tumor, and central scar are characteristic findings of renal oncocytoma. On microscopic histopathological analysis, oncocytes and large eosinophilic cells are characteristic findings of renal oncocytoma.[1]
Pathogenesis
- Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney.[2]
Gross Pathology
- The tumors are tan or mahogany brown, well circumscribed, and contain a central scar. They may achieve a large size (up to 12 cm in diameter).[2]
-
![Renal oncocytoma[3]](/images/1/19/Renal_oncocytoma1.jpg)
Renal oncocytoma[3]
![Renal oncocytoma[3]](/index.php/File:Renal_oncocytoma1.jpg)
Microscopic Pathology
- An epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli and excessive amounts of mitochondria.[1]
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![Renal oncocytoma[4]](/images/a/ad/Renal_oncocytoma2.jpg)
Renal oncocytoma[4]
![Renal oncocytoma[4]](/index.php/File:Renal_oncocytoma2.jpg)
Genetics
- Gene involved in the pathogenesis of renal concocytoma may include mtDNA MTND6.[5]
References
- ↑ 1.0 1.1 Palmer WE, Chew FS (1991). "Renal oncocytoma". AJR Am J Roentgenol. 156 (6): 1144. doi:10.2214/ajr.156.6.2028856. PMID 2028856.
- ↑ 2.0 2.1 Velasquez G, Glass TA, D'Souza VJ, Formanek AG (1984). "Multiple oncocytomas and renal carcinoma". AJR Am J Roentgenol. 142 (1): 123–4. doi:10.2214/ajr.142.1.123. PMID 6606945.
- ↑ Renla oncocytoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Renal_oncocytoma Accessed on October, 29 2015
- ↑ Renla oncocytoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Renal_oncocytoma Accessed on October, 29 2015
- ↑ Bartoletti-Stella A, Salfi NC, Ceccarelli C, Attimonelli M, Romeo G, Gasparre G (2011). "Mitochondrial DNA mutations in oncocytic adnexal lacrimal glands of the conjunctiva". Archives of Ophthalmology (Chicago, Ill. : 1960). 129 (5): 664–6. doi:10.1001/archophthalmol.2011.95. PMID 21555623.