Sandbox:DDx HEENT

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  • 30-50 yo Caucasian women
  • Ionizing radiation exposure
  • Positive family history
  • Asymptomatic painless neck nodule


  • Elevated thyroglobulin level
  • HBME-1 stain +ve
  • ATP5E stain +ve
  • Orphan Annie eye nuclear inclusions
  • Psammoma bodies
  • Unencapsulated
  • Lymphatic spread
  • Multifocal
  • RET proto-oncogene activation
  • BRAF oncogene activation
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