Cystic nephroma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

On gross pathology, large, unilateral, multiloculated, and well-encapsulated cystic tumor is the characteristic finding of cystic nephroma. On microscopic histopathological analysis, cysts lined by a simple epithelium with a hobnail morphology and ovarian-like stroma are characteristic findings of cystic nephroma.

Gross Pathology

Characteristic findings of cystic nephroma on gross pathology include:

Large, unilateral, and multiloculated cystic tumor
Well-encapsulated
Nodular surface

Microscopic Pathology

The characteristics of cystic nephromas include:

Cysts lined by a simple epithelium with a hobnail morphology（i.e. the nuclei of the cyst lining epithelium bulges into the lumen of the cysts）
Ovarian-like stroma

Spindle cell morphology
Basophilic cytoplasm

Cystic nephroma^[1]

Genetics

DICER1 mutations are involved in the pathogenesis of cystic nephroma.^[2]

References

↑ Cystic nephroma. Wikipedia 2015. https://en.wikipedia.org/wiki/Cystic_nephroma#/media/File:Cystic_nephroma_high_mag.jpg Accessed on October, 30 2015
↑ Doros LA, Rossi CT, Yang J, Field A, Williams GM, Messinger Y, Cajaiba MM, Perlman EJ, A Schultz K, Cathro HP, Legallo RD, LaFortune KA, Chikwava KR, Faria P, Geller JI, Dome JS, Mullen EA, Gratias EJ, Dehner LP, Hill DA (2014). "DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma". Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 27 (9): 1267–80. doi:10.1038/modpathol.2013.242. PMC 4117822. PMID 24481001.

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[1] Cystic nephroma. Wikipedia 2015. https://en.wikipedia.org/wiki/Cystic_nephroma#/media/File:Cystic_nephroma_high_mag.jpg Accessed on October, 30 2015

[pmid24481001-2] Doros LA, Rossi CT, Yang J, Field A, Williams GM, Messinger Y, Cajaiba MM, Perlman EJ, A Schultz K, Cathro HP, Legallo RD, LaFortune KA, Chikwava KR, Faria P, Geller JI, Dome JS, Mullen EA, Gratias EJ, Dehner LP, Hill DA (2014). "DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma". Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 27 (9): 1267–80. doi:10.1038/modpathol.2013.242. PMC 4117822. PMID 24481001.

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