Waldenström's macroglobulinemia risk factors
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Monoclonal gammopathy of undetermined significance
Monoclonal gammopathy of undetermined significance itself does not cause health problems, but each year about 1% to 2% of people go on to develop a related cancer like multiple myeloma, Waldenström's macroglobulinemia, lymphoma or another serious health problem like amyloidosis.
Age
The risk of Waldenström's macroglobulinemia goes up with age. It is rare among people younger than 50 years old.
Race
Waldenström's macroglobulinemia is more common among whites than among African Americans.
Sex
Men are more likely than women to develop Waldenström's macroglobulinemia.
Heredity
About 1 in 5 people with Waldenström's macroglobulinemia has a close relative with Waldenström's macroglobulinemia or with a related B-cell disease, such as MGUS or certain types of lymphoma or leukemia.
Hepatitis C
Some studies have found that people with chronic hepatitis C infection might be more likely to develop Waldenström's macroglobulinemia than people without the virus.
Immune Diseases
Some research has suggested that people with certain types of autoimmune disease, such as Sjögren (Sjogren) syndrome, might be at higher risk for Waldenström's macroglobulinemia.