Waldenström's macroglobulinemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and Symptoms
Patients with WM may present with various symptoms.
- Approximately 30% of the patients are asymptomatic (smoldering WM).
- Anemia with mean hemoglobin less than 10 g/dL - fatigue
- Bone marrow infiltration: cause anemia & pancytopenia
- Extramedullary infiltration - hepatomegaly, splenomegaly, lymphadenopathy
- Hyperviscosity - oronasal bleeding, retinal hemorrhage with blurring or loss of vision, headache, vertigo, ataxia
- IgM monoclonal proteins - peripheral neuropathy[1]
References
- ↑ Monge J, Braggio E, Ansell SM (2013). "Genetic factors and pathogenesis of Waldenström's macroglobulinemia". Curr Oncol Rep. 15 (5): 450–6. doi:10.1007/s11912-013-0331-7. PMC 3807757. PMID 23901022.