Essential thrombocytosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Laboratory findings consistent with the diagnosis of essential thrombocytosis include abnormal complete blood count (CBC), elevated platelet count, peripheral blood smear showing large platelets, megakaryocyte fragments and platelet aggregates,[1] presence of JAK2 mutation and absence of BCR-ABL or Philadelphia chromosome. Leukocytosis, erythrocytosis, and mild anemia may be present. Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis as per WHO definition[2].
Lab tests for the diagnosis of essential thrombocytosis include tests to rule out reactive or secondary causes of thrombocytosis. ET remains a diagnosis of exclusion. The tests include abnormal complete blood count (CBC), peripheral blood smear, cytogenetic studies including Philadelphia chromosome or BCR-ABL assay, and the presence of JAK2 V617F mutations. Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis[2]as per WHO definition.
Laboratory findings
Essential thrombocytosis remains a diagnosis of exclusion that needs to rule out reactive or secondary causes of thrombocytosis . Laboratory tests for the diagnosis of essential thrombocytosis include the following[3]:
- Complete blood count (CBC)
- Elevated platelet count
- Leukocytosis, erythrocytosis, and mild anemia may be present
- Peripheral blood smear shows large platelets, megakaryocyte fragments and platelet aggregates[4]
- To rule out inflammatory disorders
- Erythrocyte sedimentation rate (ESR)
- C-reactive protein (CRP)
- Fibrinogen
- To rule out iron deficiency and polycythemia vera
- Serum ferritin
- Hematocrit
- To rule out other myeloproliferative neoplasms
- BCR-ABL or Philadelphia chromosome
- Genetic studies
- JAK2 mutation using PCR
References
- ↑ Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.
- ↑ 2.0 2.1 Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2007-04-083501 Check
|pmid=value (help). - ↑ Essential Thrombocytosis Workup. Medscape. http://emedicine.medscape.com/article/206697-workup#c8. Accessed on November 10th, 2015
- ↑ Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.