Sandbox: Bone DDx

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  • Progressive bone pain
  • Bony swelling
  • Restricted range of movement in affected limb


  • Chondroid, myxoid, and fibrous tissue components
  • Spindle cells or stellate cells in a myxoid or chondroid stroma
  • Pseudolobulated architecture
  • Lobules with hypocellular centers and hypercellular peripheries
  • Scattered calcifications


  • Metaphyseal region of long bones
  • Lobulated, eccentric radiolucent lesion with a well defined sclerotic margin
  • No periosteal reaction
  • Presence of septations, pseudotrabeculation, and geographic bone destruction
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