Sandbox: Bone DDx

Revision as of 14:20, 24 November 2015 by Haytham Allaham (talk | contribs)
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  • 30-60 yo males
  • Bone pain, progressive swelling, decreased range of motion
  • Pathologic fracture
  • Positive history of radiation exposure or bone infarct
  • Fixed, firm mass to a localized area of tenderness
  • Neurologic or vascular defect
  • Highly destructive with a wide zone of transition
  • Expansile large soft tissue mass extending from the bone
  • Periosteal reaction is uncommon
  • Elevated mitotic activity
  • Highly cellular fibroblastic proliferation
  • Herring bone pattern and spindle cell lesions
  • Long dark nuclei with increased granular chromatin
  • Scant cytoplasm
  • Vimentin +ve
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