Sandbox: Bone DDx
- 20-30 yo female
- Bone pain and swelling
- Pathologic fracture
- Paget disease of bone
- Localised bone tenderness
- Epiphyses of the long bones
- Solitary expansile eccentrically-placed lytic lesion
- Intratumoral hemorrhage present
- Tumor extends into the subchondral plate
- Uniform and regular distribution of multinucleated giant cells and mononuclear stromal cells
- Hemorrhage, necrosis, and hemosiderin deposition
- Elevated mitotic figures
acid phosphatase +ve
alpha-1-antitrypsin +ve
alpha-1-antichymotrypsin +ve
Ki-67 +ve