Polycythemia vera (patient information)
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Polycythemia vera |
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Polycythemia vera On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
What are the symptoms of Polycythemia vera?
Symptoms may include any of the following:
Trouble breathing when lying down Dizziness Excess bleeding Full feeling in the left upper abdomen (due to enlarged spleen) Headache Itchiness, especially after a warm bath Red skin coloring, especially of the face Shortness of breath Symptoms of blood clots in veins near the skin surface (phlebitis)
Other symptoms that may occur with this disease:
Bluish skin color Fatigue Red skin spots Vision problems
What causes Polycythemia vera?
Polycythemia vera is a disorder of the bone marrow. It mainly causes too many red blood cells to be produced. The numbers of white blood cells and platelets may also be higher than normal.
This is a rare disorder that occurs more often in men than in women. It is not usually seen in people under age 40. The problem is often linked to a gene defect called JAK2V617F. The cause of this gene defect is unknown.
Who is at highest risk?
When to seek urgent medical care?
Diagnosis
The health care provider will perform a physical exam. You may also have the following tests:
Bone marrow biopsy Complete blood count with differential Comprehensive metabolic panel Erythropoietin level Genetic test for the JAK2V617F mutation Oxygen saturation of the blood Red blood cell mass Vitamin B12 level
This disease may also affect the results of the following tests:
ESR Lactate dehydrogenase (LDH) Leukocyte alkaline phosphatase Platelet aggregation test Serum uric acid
Treatment options
Where to find medical care for Polycythemia vera?
Directions to Hospitals Treating Polycythemia vera